The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precur...

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Detalles Bibliográficos
Autores principales: Tiedje, Christopher, Ronkina, Natalia, Tehrani, Mohammad, Dhamija, Sonam, Laass, Kathrin, Holtmann, Helmut, Kotlyarov, Alexey, Gaestel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459988/
https://www.ncbi.nlm.nih.gov/pubmed/23028373
http://dx.doi.org/10.1371/journal.pgen.1002977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459988/
https://www.ncbi.nlm.nih.gov/pubmed/23028373
http://dx.doi.org/10.1371/journal.pgen.1002977

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