TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver

Peripheral insulin resistance contributes to the development of type 2 diabetes. TCF7L2 has been tightly associated with this disease, although the exact mechanism was largely elusive. Here we propose a novel role of TCF7L2 in hepatic glucose metabolism in mammals. Expression of medium and short iso...

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Detalles Bibliográficos
Autores principales: Oh, Kyoung-Jin, Park, Jinyoung, Kim, Su Sung, Oh, Hyunhee, Choi, Cheol Soo, Koo, Seung-Hoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459990/
https://www.ncbi.nlm.nih.gov/pubmed/23028378
http://dx.doi.org/10.1371/journal.pgen.1002986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459990/
https://www.ncbi.nlm.nih.gov/pubmed/23028378
http://dx.doi.org/10.1371/journal.pgen.1002986

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