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The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases
The class 1 PI3Ks are lipid kinases with key roles in cell surface receptor-triggered signal transduction pathways. Two isoforms of the catalytic subunits, p110γ and p110δ, are enriched in leucocytes in which they promote activation, cellular growth, proliferation, differentiation and survival throu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bentham Open
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460535/ https://www.ncbi.nlm.nih.gov/pubmed/23028409 http://dx.doi.org/10.2174/1874312901206010245 |