Destabilizing Domains Mediate Reversible Transgene Expression in the Brain

Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a destabilizing domain (DD) of the Escherichia coli dihy...

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Detalles Bibliográficos
Autores principales: Tai, Khalid, Quintino, Luis, Isaksson, Christina, Gussing, Fredrik, Lundberg, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460874/
https://www.ncbi.nlm.nih.gov/pubmed/23029456
http://dx.doi.org/10.1371/journal.pone.0046269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460874/
https://www.ncbi.nlm.nih.gov/pubmed/23029456
http://dx.doi.org/10.1371/journal.pone.0046269

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