Cargando…
Destabilizing Domains Mediate Reversible Transgene Expression in the Brain
Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a destabilizing domain (DD) of the Escherichia coli dihy...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460874/ https://www.ncbi.nlm.nih.gov/pubmed/23029456 http://dx.doi.org/10.1371/journal.pone.0046269 |