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Interaction of Nuclease Colicins with Membranes: Insertion Depth Correlates with Bilayer Perturbation

BACKGROUND: Protein transport across cellular membranes is an important aspect of toxin biology. Escherichia coli cell killing by nuclease colicins occurs through DNA (DNases) or RNA (RNases) hydrolysis and to this end their cytotoxic domains require transportation across two sets of membranes. In o...

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Detalles Bibliográficos
Autores principales: Vankemmelbeke, Mireille, O′Shea, Paul, James, Richard, Penfold, Christopher N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460906/
https://www.ncbi.nlm.nih.gov/pubmed/23029560
http://dx.doi.org/10.1371/journal.pone.0046656