Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells

BACKGROUND: Cellular stress responses trigger signaling cascades that inhibit proliferation and protein translation to help alleviate the stress or if the stress cannot be overcome induce apoptosis. In recent studies, we demonstrated the ability of lovastatin, an inhibitor of mevalonate synthesis, t...

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Detalles Bibliográficos
Autores principales: Ma, Laurie, Niknejad, Nima, Gorn-Hondermann, Ivan, Dayekh, Khalil, Dimitroulakos, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460930/
https://www.ncbi.nlm.nih.gov/pubmed/23029387
http://dx.doi.org/10.1371/journal.pone.0046055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460930/
https://www.ncbi.nlm.nih.gov/pubmed/23029387
http://dx.doi.org/10.1371/journal.pone.0046055

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