5-Aza-2′-deoxycytidine Leads to Reduced Embryo Implantation and Reduced Expression of DNA Methyltransferases and Essential Endometrial Genes

BACKGROUND: The DNA demethylating agent 5-aza-2′-deoxycytidine (5-aza-CdR) incorporates into DNA and decreases DNA methylation, sparking interest in its use as a potential therapeutic agent. We aimed to determine the effects of maternal 5-aza-CdR treatment on embryo implantation in the mouse and to...

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Detalles Bibliográficos
Autores principales: Ding, Yu-Bin, Long, Chun-Lan, Liu, Xue-Qing, Chen, Xue-Mei, Guo, Liang-Rui, Xia, Yin-Yin, He, Jun-Lin, Wang, Ying-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460940/
https://www.ncbi.nlm.nih.gov/pubmed/23028963
http://dx.doi.org/10.1371/journal.pone.0045364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460940/
https://www.ncbi.nlm.nih.gov/pubmed/23028963
http://dx.doi.org/10.1371/journal.pone.0045364

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