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When the Lowest Energy Does Not Induce Native Structures: Parallel Minimization of Multi-Energy Values by Hybridizing Searching Intelligences

BACKGROUND: Protein structure prediction (PSP), which is usually modeled as a computational optimization problem, remains one of the biggest challenges in computational biology. PSP encounters two difficult obstacles: the inaccurate energy function problem and the searching problem. Even if the lowe...

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Detalles Bibliográficos
Autores principales: Lü, Qiang, Xia, Xiao-Yan, Chen, Rong, Miao, Da-Jun, Chen, Sha-Sha, Quan, Li-Jun, Li, Hai-Ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460973/
https://www.ncbi.nlm.nih.gov/pubmed/23028708
http://dx.doi.org/10.1371/journal.pone.0044967