Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial colocalization of chromosomal breakpoints. The “contact fi...

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Detalles Bibliográficos
Autores principales: Engreitz, Jesse M., Agarwala, Vineeta, Mirny, Leonid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460994/
https://www.ncbi.nlm.nih.gov/pubmed/23028501
http://dx.doi.org/10.1371/journal.pone.0044196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460994/
https://www.ncbi.nlm.nih.gov/pubmed/23028501
http://dx.doi.org/10.1371/journal.pone.0044196

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