Decreased Mdm2 Expression Inhibits Tumor Development and Extends Survival Independent of Arf and Dependent on p53

Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development. Moreover, inhibition of oncogene-induced tumorigenesis relies on Arf a...

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Detalles Bibliográficos
Autores principales: Eischen, Christine M., Boyd, Kelli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461014/
https://www.ncbi.nlm.nih.gov/pubmed/23029416
http://dx.doi.org/10.1371/journal.pone.0046148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461014/
https://www.ncbi.nlm.nih.gov/pubmed/23029416
http://dx.doi.org/10.1371/journal.pone.0046148

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