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The prognostic importance of miR-21 in stage II colon cancer: a population-based study

BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-...

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Autores principales: Kjaer-Frifeldt, S, Hansen, T F, Nielsen, B S, Joergensen, S, Lindebjerg, J, Soerensen, F B, dePont Christensen, R, Jakobsen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461159/
https://www.ncbi.nlm.nih.gov/pubmed/23011541
http://dx.doi.org/10.1038/bjc.2012.365
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author Kjaer-Frifeldt, S
Hansen, T F
Nielsen, B S
Joergensen, S
Lindebjerg, J
Soerensen, F B
dePont Christensen, R
Jakobsen, A
author_facet Kjaer-Frifeldt, S
Hansen, T F
Nielsen, B S
Joergensen, S
Lindebjerg, J
Soerensen, F B
dePont Christensen, R
Jakobsen, A
author_sort Kjaer-Frifeldt, S
collection PubMed
description BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR=1.26; 95% CI: 1.15–1.60; P<0.001. In Cox regression analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR=1.41; 95% CI: 1.19–1.67; P<0.001. CONCLUSION: The present study showed that increasing miR-21 expression levels were significantly correlated to decreasing RF-CSS. Further investigations of the clinical importance of miR-21 in the selection of high-risk stage II colon cancer patients are merited.
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spelling pubmed-34611592013-09-25 The prognostic importance of miR-21 in stage II colon cancer: a population-based study Kjaer-Frifeldt, S Hansen, T F Nielsen, B S Joergensen, S Lindebjerg, J Soerensen, F B dePont Christensen, R Jakobsen, A Br J Cancer Epidemiology BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR=1.26; 95% CI: 1.15–1.60; P<0.001. In Cox regression analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR=1.41; 95% CI: 1.19–1.67; P<0.001. CONCLUSION: The present study showed that increasing miR-21 expression levels were significantly correlated to decreasing RF-CSS. Further investigations of the clinical importance of miR-21 in the selection of high-risk stage II colon cancer patients are merited. Nature Publishing Group 2012-09-25 2012-09-25 /pmc/articles/PMC3461159/ /pubmed/23011541 http://dx.doi.org/10.1038/bjc.2012.365 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Kjaer-Frifeldt, S
Hansen, T F
Nielsen, B S
Joergensen, S
Lindebjerg, J
Soerensen, F B
dePont Christensen, R
Jakobsen, A
The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title_full The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title_fullStr The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title_full_unstemmed The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title_short The prognostic importance of miR-21 in stage II colon cancer: a population-based study
title_sort prognostic importance of mir-21 in stage ii colon cancer: a population-based study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461159/
https://www.ncbi.nlm.nih.gov/pubmed/23011541
http://dx.doi.org/10.1038/bjc.2012.365
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