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The prognostic importance of miR-21 in stage II colon cancer: a population-based study
BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461159/ https://www.ncbi.nlm.nih.gov/pubmed/23011541 http://dx.doi.org/10.1038/bjc.2012.365 |
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author | Kjaer-Frifeldt, S Hansen, T F Nielsen, B S Joergensen, S Lindebjerg, J Soerensen, F B dePont Christensen, R Jakobsen, A |
author_facet | Kjaer-Frifeldt, S Hansen, T F Nielsen, B S Joergensen, S Lindebjerg, J Soerensen, F B dePont Christensen, R Jakobsen, A |
author_sort | Kjaer-Frifeldt, S |
collection | PubMed |
description | BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR=1.26; 95% CI: 1.15–1.60; P<0.001. In Cox regression analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR=1.41; 95% CI: 1.19–1.67; P<0.001. CONCLUSION: The present study showed that increasing miR-21 expression levels were significantly correlated to decreasing RF-CSS. Further investigations of the clinical importance of miR-21 in the selection of high-risk stage II colon cancer patients are merited. |
format | Online Article Text |
id | pubmed-3461159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34611592013-09-25 The prognostic importance of miR-21 in stage II colon cancer: a population-based study Kjaer-Frifeldt, S Hansen, T F Nielsen, B S Joergensen, S Lindebjerg, J Soerensen, F B dePont Christensen, R Jakobsen, A Br J Cancer Epidemiology BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR=1.26; 95% CI: 1.15–1.60; P<0.001. In Cox regression analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR=1.41; 95% CI: 1.19–1.67; P<0.001. CONCLUSION: The present study showed that increasing miR-21 expression levels were significantly correlated to decreasing RF-CSS. Further investigations of the clinical importance of miR-21 in the selection of high-risk stage II colon cancer patients are merited. Nature Publishing Group 2012-09-25 2012-09-25 /pmc/articles/PMC3461159/ /pubmed/23011541 http://dx.doi.org/10.1038/bjc.2012.365 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Kjaer-Frifeldt, S Hansen, T F Nielsen, B S Joergensen, S Lindebjerg, J Soerensen, F B dePont Christensen, R Jakobsen, A The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title | The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title_full | The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title_fullStr | The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title_full_unstemmed | The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title_short | The prognostic importance of miR-21 in stage II colon cancer: a population-based study |
title_sort | prognostic importance of mir-21 in stage ii colon cancer: a population-based study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461159/ https://www.ncbi.nlm.nih.gov/pubmed/23011541 http://dx.doi.org/10.1038/bjc.2012.365 |
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