Cargando…
Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson’s disease
Mitochondrial oxidant stress is widely viewed as critical to pathogenesis in Parkinson’s disease. But the origins of this stress are poorly defined. One possibility is that it arises from the metabolic demands associated with regenerative activity. To test this hypothesis, neurons in the dorsal moto...
Autores principales: | Goldberg, Joshua A., Guzman, Jaime N., Estep, Chad M., Ilijic, Ema, Kondapalli, Jyothisri, Sanchez-Padilla, Javier, Surmeier, D. James |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461271/ https://www.ncbi.nlm.nih.gov/pubmed/22941107 http://dx.doi.org/10.1038/nn.3209 |
Ejemplares similares
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
por: Guzman, Jaime N., et al.
Publicado: (2010) -
Mutant huntingtin enhances activation of dendritic Kv4 K(+) channels in striatal spiny projection neurons
por: Carrillo-Reid, Luis, et al.
Publicado: (2019) -
α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin
por: Lieberman, Ori J., et al.
Publicado: (2017) -
Ca(2+) channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
por: Zampese, Enrico, et al.
Publicado: (2022) -
Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase
por: Sanchez–Padilla, J., et al.
Publicado: (2014)