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Overexpression of HIF Prolyl-Hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension

Renal medullary hypoxia-inducible factor (HIF)-1α and its target genes, such as haem oxygenase and nitric oxide synthase, have been indicated to play an important role in the regulation of sodium excretion and blood pressure. HIF prolyl hydroxylase domain-containing proteins (PHDs) are major enzymes...

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Detalles Bibliográficos
Autores principales: Zhu, Qing, Liu, Miao, Han, Wei-Qing, Li, Pin-Lan, Wang, Zhengchao, Li, Ningjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461349/
https://www.ncbi.nlm.nih.gov/pubmed/22686466
http://dx.doi.org/10.1111/j.1582-4934.2012.01590.x