Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation. As a result, MLN4924 causes accumulation of several key substrates of CRLs and effectively suppresses tumor cell growth by induci...

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Detalles Bibliográficos
Autores principales: Zhao, Y, Xiong, X, Jia, L, Sun, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461362/
https://www.ncbi.nlm.nih.gov/pubmed/22951983
http://dx.doi.org/10.1038/cddis.2012.125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461362/
https://www.ncbi.nlm.nih.gov/pubmed/22951983
http://dx.doi.org/10.1038/cddis.2012.125

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