Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis

In this study, we have analysed the apoptotic effects of the ubiquitous environmental toxin benzo[a]pyrene (BP) in HaCaT cells and human keratinocytes. Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concen...

Descripción completa

Detalles Bibliográficos
Autores principales: Stolpmann, K, Brinkmann, J, Salzmann, S, Genkinger, D, Fritsche, E, Hutzler, C, Wajant, H, Luch, A, Henkler, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461363/
https://www.ncbi.nlm.nih.gov/pubmed/22951985
http://dx.doi.org/10.1038/cddis.2012.127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461363/
https://www.ncbi.nlm.nih.gov/pubmed/22951985
http://dx.doi.org/10.1038/cddis.2012.127

Ejemplares similares