Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

The products of genes that cause cerebral cavernous malformations (CCM1/KRIT1, CCM2, and CCM3) physically interact. CCM1/KRIT1 links this complex to endothelial cell (EC) junctions and maintains junctional integrity in part by inhibiting RhoA. Heart of glass (HEG1), a transmembrane protein, associat...

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Detalles Bibliográficos
Autores principales: Gingras, Alexandre R., Liu, Jian J., Ginsberg, Mark H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461514/
https://www.ncbi.nlm.nih.gov/pubmed/23007647
http://dx.doi.org/10.1083/jcb.201205109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461514/
https://www.ncbi.nlm.nih.gov/pubmed/23007647
http://dx.doi.org/10.1083/jcb.201205109

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