Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

The spindle assembly checkpoint (SAC) is essential to ensure proper chromosome segregation and thereby maintain genomic stability. The SAC monitors chromosome attachment, and any unattached chromosomes generate a “wait anaphase” signal that blocks chromosome segregation. The target of the SAC is Cdc...

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Detalles Bibliográficos
Autores principales: Izawa, Daisuke, Pines, Jonathon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461516/
https://www.ncbi.nlm.nih.gov/pubmed/23007648
http://dx.doi.org/10.1083/jcb.201205170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461516/
https://www.ncbi.nlm.nih.gov/pubmed/23007648
http://dx.doi.org/10.1083/jcb.201205170

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