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Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
The spindle assembly checkpoint (SAC) is essential to ensure proper chromosome segregation and thereby maintain genomic stability. The SAC monitors chromosome attachment, and any unattached chromosomes generate a “wait anaphase” signal that blocks chromosome segregation. The target of the SAC is Cdc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461516/ https://www.ncbi.nlm.nih.gov/pubmed/23007648 http://dx.doi.org/10.1083/jcb.201205170 |