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Activation Kinetics and Off-Target Effects of Thymus-Initiated Cre Transgenes
The bacteriophage enzyme Cre is a site-specific recombinase widely used to delete loxP-flanked DNA sequences in lineage-specific fashion. Several mouse lines that direct Cre expression to lymphoid progenitors in the thymus have been established, but a side-by-side comparison of when they first becom...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462198/ https://www.ncbi.nlm.nih.gov/pubmed/23049709 http://dx.doi.org/10.1371/journal.pone.0046590 |