Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties

Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid–base properties were evaluated. The dissociation constant (pK (a)) of compounds 1–22 were determinated by potentiometric titration and calculated usin...

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Detalles Bibliográficos
Autores principales: Zagórska, Agnieszka, Czopek, Anna, Pawłowski, Maciej, Dybała, Małgorzata, Siwek, Agata, Nowak, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462310/
https://www.ncbi.nlm.nih.gov/pubmed/23049232
http://dx.doi.org/10.1007/s00044-011-9883-y
Descripción
Sumario:Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid–base properties were evaluated. The dissociation constant (pK (a)) of compounds 1–22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached.

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