Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties

Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid–base properties were evaluated. The dissociation constant (pK (a)) of compounds 1–22 were determinated by potentiometric titration and calculated usin...

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Autores principales: Zagórska, Agnieszka, Czopek, Anna, Pawłowski, Maciej, Dybała, Małgorzata, Siwek, Agata, Nowak, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462310/
https://www.ncbi.nlm.nih.gov/pubmed/23049232
http://dx.doi.org/10.1007/s00044-011-9883-y
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author Zagórska, Agnieszka
Czopek, Anna
Pawłowski, Maciej
Dybała, Małgorzata
Siwek, Agata
Nowak, Gabriel
author_facet Zagórska, Agnieszka
Czopek, Anna
Pawłowski, Maciej
Dybała, Małgorzata
Siwek, Agata
Nowak, Gabriel
author_sort Zagórska, Agnieszka
collection PubMed
description Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid–base properties were evaluated. The dissociation constant (pK (a)) of compounds 1–22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached.
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spelling pubmed-34623102012-10-03 Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties Zagórska, Agnieszka Czopek, Anna Pawłowski, Maciej Dybała, Małgorzata Siwek, Agata Nowak, Gabriel Med Chem Res Original Research Affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid–base properties were evaluated. The dissociation constant (pK (a)) of compounds 1–22 were determinated by potentiometric titration and calculated using pKalc 3.1 module of the Pallas system. The data from experimental methods and computational calculations were compared and suitable conclusions were reached. Springer-Verlag 2011-11-19 2012 /pmc/articles/PMC3462310/ /pubmed/23049232 http://dx.doi.org/10.1007/s00044-011-9883-y Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Research
Zagórska, Agnieszka
Czopek, Anna
Pawłowski, Maciej
Dybała, Małgorzata
Siwek, Agata
Nowak, Gabriel
Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title_full Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title_fullStr Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title_full_unstemmed Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title_short Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
title_sort serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid–base properties
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462310/
https://www.ncbi.nlm.nih.gov/pubmed/23049232
http://dx.doi.org/10.1007/s00044-011-9883-y
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