AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines

Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the ERK/MAPK, the PI3K/AKT/mTOR and the JAK/STAT3 pathways. Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in v...

Descripción completa

Detalles Bibliográficos
Autores principales: Couto, Joana P., Almeida, Ana, Daly, Laura, Sobrinho-Simões, Manuel, Bromberg, Jacqueline F., Soares, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462763/
https://www.ncbi.nlm.nih.gov/pubmed/23056499
http://dx.doi.org/10.1371/journal.pone.0046869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462763/
https://www.ncbi.nlm.nih.gov/pubmed/23056499
http://dx.doi.org/10.1371/journal.pone.0046869

Ejemplares similares