Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes

The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2 phosphorylates PRH and counteracts the inhibitory effect of this protein on cell survival by blocking the repression of VSP genes. Here we show that th...

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Detalles Bibliográficos
Autores principales: Noy, Peter, Gaston, Kevin, Jayaraman, Padma-Sheela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2012
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462996/
https://www.ncbi.nlm.nih.gov/pubmed/22874537
http://dx.doi.org/10.1016/j.leukres.2012.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462996/
https://www.ncbi.nlm.nih.gov/pubmed/22874537
http://dx.doi.org/10.1016/j.leukres.2012.07.013

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