Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness

We have used selective inhibitors to determine whether the molecular chaperone heat shock protein 90 (HSP90) has an effect on both recombinant and native human P2X1 receptors. P2X1 receptor currents in HEK293 cells were reduced by ∼70–85% by the selective HSP90 inhibitor geldanamycin (2 μm, 20 min)....

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Detalles Bibliográficos
Autores principales: Lalo, Ulyana, Jones, Sarah, Roberts, Jonathan A., Mahaut-Smith, Martyn P., Evans, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463321/
https://www.ncbi.nlm.nih.gov/pubmed/22851178
http://dx.doi.org/10.1074/jbc.M112.376566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463321/
https://www.ncbi.nlm.nih.gov/pubmed/22851178
http://dx.doi.org/10.1074/jbc.M112.376566

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