Cargando…
The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation
The AKT, GSK3 and JNK family kinases have been implicated in neuronal apoptosis associated with neuronal development and several neurodegenerative conditions. However, the mechanisms by which these kinase pathways regulate apoptosis remain unclear. In this study we have investigated the role of thes...
Autores principales: | Ambacher, Kristin K., Pitzul, Kristen B., Karajgikar, Meera, Hamilton, Alison, Ferguson, Stephen S., Cregan, Sean P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463558/ https://www.ncbi.nlm.nih.gov/pubmed/23056511 http://dx.doi.org/10.1371/journal.pone.0046885 |
Ejemplares similares
-
Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma
por: Guadagno, J, et al.
Publicado: (2013) -
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
por: Schubert, Florian, et al.
Publicado: (2018) -
Trophic Facilitation or Limitation? Comparative Effects of Pumas and Black Bears on the Scavenger Community
por: Allen, Maximilian L., et al.
Publicado: (2014) -
Trophic convergence drives morphological convergence in marine tetrapods
por: Kelley, Neil P., et al.
Publicado: (2015) -
Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma
por: Yang, Hongyan, et al.
Publicado: (2017)