A Series of Beta-Carboline Derivatives Inhibit the Kinase Activity of PLKs

Polo-like kinases play an essential role in the ordered execution of mitotic events and 4 mammalian PLK family members have been identified. Accumulating evidence indicates that PLK1 is an attractive target for anticancer drugs. In this paper, a series of beta-carboline derivatives were synthesized...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Xiaomin, Zhang, Jing, Guo, Liang, Cao, Rihui, Li, Yongzhen, Li, Ni, Ma, Qin, Wu, Jialin, Wang, Yanchang, Si, Shuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463587/
https://www.ncbi.nlm.nih.gov/pubmed/23056340
http://dx.doi.org/10.1371/journal.pone.0046546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463587/
https://www.ncbi.nlm.nih.gov/pubmed/23056340
http://dx.doi.org/10.1371/journal.pone.0046546

Ejemplares similares