Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice

BACKGROUND: The clinical uses of 2-chloro-2′-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and r...

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Detalles Bibliográficos
Autores principales: Hayes, Crystal D., Dey, Debleena, Palavicini, Juan Pablo, Wang, Hongjie, Araki, Wataru, Lakshmana, Madepalli K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463612/
https://www.ncbi.nlm.nih.gov/pubmed/23056220
http://dx.doi.org/10.1371/journal.pone.0045841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463612/
https://www.ncbi.nlm.nih.gov/pubmed/23056220
http://dx.doi.org/10.1371/journal.pone.0045841

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