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Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice
BACKGROUND: The clinical uses of 2-chloro-2′-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and r...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463612/ https://www.ncbi.nlm.nih.gov/pubmed/23056220 http://dx.doi.org/10.1371/journal.pone.0045841 |