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Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors

Cys-loop receptors constitute a superfamily of pentameric ligand-gated ion channels (pLGICs), including receptors for acetylcholine, serotonin, glycine and γ-aminobutyric acid. Several bacterial homologues have been identified that are excellent models for understanding allosteric binding of alcohol...

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Detalles Bibliográficos
Autores principales: Murail, Samuel, Howard, Rebecca J., Broemstrup, Torben, Bertaccini, Edward J., Harris, R. Adron, Trudell, James R., Lindahl, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464191/
https://www.ncbi.nlm.nih.gov/pubmed/23055913
http://dx.doi.org/10.1371/journal.pcbi.1002710