Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

The effects of disease mutations on protein structure and function have been extensively investigated, and many predictors of the functional impact of single amino acid substitutions are publicly available. The majority of these predictors are based on protein structure and evolutionary conservation...

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Detalles Bibliográficos
Autores principales: Vacic, Vladimir, Markwick, Phineus R. L., Oldfield, Christopher J., Zhao, Xiaoyue, Haynes, Chad, Uversky, Vladimir N., Iakoucheva, Lilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464192/
https://www.ncbi.nlm.nih.gov/pubmed/23055912
http://dx.doi.org/10.1371/journal.pcbi.1002709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464192/
https://www.ncbi.nlm.nih.gov/pubmed/23055912
http://dx.doi.org/10.1371/journal.pcbi.1002709

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