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Poor Cerebral Inflammatory Response in eIF2B Knock-In Mice: Implications for the Aetiology of Vanishing White Matter Disease

BACKGROUND: Mutations in any of the five subunits of eukaryotic translation initiation factor 2B (eIF2B) can lead to an inherited chronic-progressive fatal brain disease of unknown aetiology termed leucoencephalopathy with vanishing white matter (VWM). VWM is one of the most prevalent childhood whit...

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Detalles Bibliográficos
Autores principales: Cabilly, Yuval, Barbi, Mali, Geva, Michal, Marom, Liraz, Chetrit, David, Ehrlich, Marcelo, Elroy-Stein, Orna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464276/
https://www.ncbi.nlm.nih.gov/pubmed/23056417
http://dx.doi.org/10.1371/journal.pone.0046715