Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells

BACKGROUND: The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression of AurA and the effects of AurA inhibition in cancer stem cells are not yet fully understood. We investigated the expression and inhibit...

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Detalles Bibliográficos
Autores principales: Kim, Soo-Jeong, Jang, Ji Eun, Cheong, June-Won, Eom, Ju-In, Jeung, Hoi-Kyung, Kim, Yundeok, Hwang, Doh Yu, Min, Yoo Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464334/
https://www.ncbi.nlm.nih.gov/pubmed/23071472
http://dx.doi.org/10.5045/kjh.2012.47.3.178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464334/
https://www.ncbi.nlm.nih.gov/pubmed/23071472
http://dx.doi.org/10.5045/kjh.2012.47.3.178

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