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Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells
BACKGROUND: The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression of AurA and the effects of AurA inhibition in cancer stem cells are not yet fully understood. We investigated the expression and inhibit...
Autores principales: | Kim, Soo-Jeong, Jang, Ji Eun, Cheong, June-Won, Eom, Ju-In, Jeung, Hoi-Kyung, Kim, Yundeok, Hwang, Doh Yu, Min, Yoo Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464334/ https://www.ncbi.nlm.nih.gov/pubmed/23071472 http://dx.doi.org/10.5045/kjh.2012.47.3.178 |
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