Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies

BACKGROUND: Many clinical trials show no overall benefit. We examined futility analyses applied to trials with different effect sizes. METHODS: Ten randomised cancer trials were retrospectively analysed; target sample size reached in all. The hazard ratio indicated no overall benefit (n=5), or moder...

Descripción completa

Detalles Bibliográficos
Autores principales: Jitlal, M, Khan, I, Lee, S M, Hackshaw, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464764/
https://www.ncbi.nlm.nih.gov/pubmed/22878376
http://dx.doi.org/10.1038/bjc.2012.344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464764/
https://www.ncbi.nlm.nih.gov/pubmed/22878376
http://dx.doi.org/10.1038/bjc.2012.344

Ejemplares similares