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Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies

BACKGROUND: Many clinical trials show no overall benefit. We examined futility analyses applied to trials with different effect sizes. METHODS: Ten randomised cancer trials were retrospectively analysed; target sample size reached in all. The hazard ratio indicated no overall benefit (n=5), or moder...

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Detalles Bibliográficos
Autores principales:	Jitlal, M, Khan, I, Lee, S M, Hackshaw, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464764/ https://www.ncbi.nlm.nih.gov/pubmed/22878376 http://dx.doi.org/10.1038/bjc.2012.344

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