The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

BACKGROUND: Fatty acid synthase (FASN) is overexpressed and associated with poor prognosis in several human cancers. Here, we investigate the effect of FASN inhibitors on the metastatic spread and angiogenesis in experimental melanomas and cultured melanoma cells. METHODS: The lung colonisation assa...

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Detalles Bibliográficos
Autores principales: Seguin, F, Carvalho, M A, Bastos, D C, Agostini, M, Zecchin, K G, Alvarez-Flores, M P, Chudzinski-Tavassi, A M, Coletta, R D, Graner, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464771/
https://www.ncbi.nlm.nih.gov/pubmed/22892389
http://dx.doi.org/10.1038/bjc.2012.355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464771/
https://www.ncbi.nlm.nih.gov/pubmed/22892389
http://dx.doi.org/10.1038/bjc.2012.355

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