Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies

Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R, CD22, and LeY, with stabilized Dig-binding variabl...

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Detalles Bibliográficos
Autores principales: Schneider, Britta, Grote, Michael, John, Matthias, Haas, Alexander, Bramlage, Birgit, lckenstein, Ludger M, Jahn-Hofmann, Kerstin, Bauss, Frieder, Cheng, Weijun, Croasdale, Rebecca, Daub, Karin, Dill, Simone, Hoffmann, Eike, Lau, Wilma, Burtscher, Helmut, Ludtke, James L, Metz, Silke, Mundigl, Olaf, Neal, Zane C, Scheuer, Werner, Stracke, Jan, Herweijer, Hans, Brinkmann, Ulrjch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464882/
https://www.ncbi.nlm.nih.gov/pubmed/23344238
http://dx.doi.org/10.1038/mtna.2012.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464882/
https://www.ncbi.nlm.nih.gov/pubmed/23344238
http://dx.doi.org/10.1038/mtna.2012.39

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