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Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films

BACKGROUND: Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treatment of diabetes, to provide greater therapeutic effect, bypass first pass effec...

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Autores principales: Prasanna, R Indira, Sankari, K Uma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465157/
https://www.ncbi.nlm.nih.gov/pubmed/23071957
http://dx.doi.org/10.4103/2230-973X.96923
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author Prasanna, R Indira
Sankari, K Uma
author_facet Prasanna, R Indira
Sankari, K Uma
author_sort Prasanna, R Indira
collection PubMed
description BACKGROUND: Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treatment of diabetes, to provide greater therapeutic effect, bypass first pass effect and to improve patient compliance upon administering buccal drug delivery of Glibenclamide (G) have not been tested literally. Hence, the present study was designed to develop the buccal mucoadhesive films of glibenclamide by solvent casting technique; that is by using different polymers such as Hydroxy Propyl Methyl Cellulose 15 cps (HPMC), carbopol (CP), and poly vinyl pyrrolidone. Propylene glycol, which served the purpose of plasticizer as well as penetration enhancer and the backing membrane used was aluminium foil. MATERIALS AND METHODS: The films were subjected to physicochemical parameters, in-vitro drug release and ex vivo bucco adhesive strength. RESULTS: The satisfactory results were obtained in all prepared formulation and based on the results G14 [HPMC (150 mg) + CP(20 mg) + PVP (30 mg)] was the best one compared to others. The drug release of all formulation follows zero order kinetics by diffusion mechanism of non-fickian diffusion type. Ex vivo, buccal permeation studies by using sheep buccal mucosa and finally stability studies by using human saliva were carried out for the optimized formulation G14.Good correlation was observed between in-vitro and in vivo correlation, thus revealing the ability of the formulation to reproduce the in-vitro release pattern through the in vivo. CONCLUSION: Glibenclamide muck-adhesive buccal films could be promising one as they, increase bioavailability by bypassing the first pass effect, minimize the dose, reduces the side effects, and improve patient compliance and also glibenclamide might be a right and suitable candidate for oral controlled drug delivery via buccoadhesive films.
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spelling pubmed-34651572012-10-15 Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films Prasanna, R Indira Sankari, K Uma Int J Pharm Investig Original Research Article BACKGROUND: Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treatment of diabetes, to provide greater therapeutic effect, bypass first pass effect and to improve patient compliance upon administering buccal drug delivery of Glibenclamide (G) have not been tested literally. Hence, the present study was designed to develop the buccal mucoadhesive films of glibenclamide by solvent casting technique; that is by using different polymers such as Hydroxy Propyl Methyl Cellulose 15 cps (HPMC), carbopol (CP), and poly vinyl pyrrolidone. Propylene glycol, which served the purpose of plasticizer as well as penetration enhancer and the backing membrane used was aluminium foil. MATERIALS AND METHODS: The films were subjected to physicochemical parameters, in-vitro drug release and ex vivo bucco adhesive strength. RESULTS: The satisfactory results were obtained in all prepared formulation and based on the results G14 [HPMC (150 mg) + CP(20 mg) + PVP (30 mg)] was the best one compared to others. The drug release of all formulation follows zero order kinetics by diffusion mechanism of non-fickian diffusion type. Ex vivo, buccal permeation studies by using sheep buccal mucosa and finally stability studies by using human saliva were carried out for the optimized formulation G14.Good correlation was observed between in-vitro and in vivo correlation, thus revealing the ability of the formulation to reproduce the in-vitro release pattern through the in vivo. CONCLUSION: Glibenclamide muck-adhesive buccal films could be promising one as they, increase bioavailability by bypassing the first pass effect, minimize the dose, reduces the side effects, and improve patient compliance and also glibenclamide might be a right and suitable candidate for oral controlled drug delivery via buccoadhesive films. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3465157/ /pubmed/23071957 http://dx.doi.org/10.4103/2230-973X.96923 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Prasanna, R Indira
Sankari, K Uma
Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title_full Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title_fullStr Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title_full_unstemmed Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title_short Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
title_sort design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465157/
https://www.ncbi.nlm.nih.gov/pubmed/23071957
http://dx.doi.org/10.4103/2230-973X.96923
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