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Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal

Inhibition of glycogen synthase kinase-3 (Gsk3) supports mouse embryonic stem cells (ESCs) by modulating Tcf3, but the critical targets downstream of Tcf3 are unclear. We analyzed the intersection between genome localization and transcriptome data sets to identify genes repressed by Tcf3. Among thes...

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Detalles Bibliográficos
Autores principales: Martello, Graziano, Sugimoto, Toshimi, Diamanti, Evangelia, Joshi, Anagha, Hannah, Rebecca, Ohtsuka, Satoshi, Göttgens, Berthold, Niwa, Hitoshi, Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465555/
https://www.ncbi.nlm.nih.gov/pubmed/23040478
http://dx.doi.org/10.1016/j.stem.2012.06.008