Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum

NBP (nitrogen-containing bisphosphonate) drugs protect against excessive osteoclast-mediated bone resorption. After binding to bone mineral, they are taken up selectively by the osteoclasts and inhibit the essential enzyme FDPS (farnesyl diphosphate synthase). NBPs inhibit also growth of amoebae of...

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Detalles Bibliográficos
Autores principales: Nuttall, James M., Hettema, Ewald H., Watts, Donald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465988/
https://www.ncbi.nlm.nih.gov/pubmed/22849378
http://dx.doi.org/10.1042/BJ20120750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465988/
https://www.ncbi.nlm.nih.gov/pubmed/22849378
http://dx.doi.org/10.1042/BJ20120750

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