Cargando…

Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum

NBP (nitrogen-containing bisphosphonate) drugs protect against excessive osteoclast-mediated bone resorption. After binding to bone mineral, they are taken up selectively by the osteoclasts and inhibit the essential enzyme FDPS (farnesyl diphosphate synthase). NBPs inhibit also growth of amoebae of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nuttall, James M., Hettema, Ewald H., Watts, Donald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465988/ https://www.ncbi.nlm.nih.gov/pubmed/22849378 http://dx.doi.org/10.1042/BJ20120750

Ejemplares similares

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
por: Jordão, Fabiana M, et al.
Publicado: (2013)

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
por: Gadelha, Ana Paula R., et al.
Publicado: (2020)

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
por: Kim, Hee Yeon, et al.
Publicado: (2018)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
por: Gabriel, Heloisa B, et al.
Publicado: (2018)

Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells
por: Oike, Asami, et al.
Publicado: (2022)

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma
por: Abate, Mario, et al.
Publicado: (2017)

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
por: Ory, B, et al.
Publicado: (2008)

Modifications of lysosomal enzymes in Dictyostelium discoideum
por: Freeze, Hudson H.
Publicado: (1986)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants()
por: Tsoumpra, Maria K., et al.
Publicado: (2015)

Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants
por: Guo, Dong, et al.
Publicado: (2015)

Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus
por: Samori, Petrus Yesaya, et al.
Publicado: (2017)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
por: Gong, Daoyong, et al.
Publicado: (2022)

Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues
por: Hou, Anwei, et al.
Publicado: (2021)

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
por: Zhang, Dongrui, et al.
Publicado: (2023)

Molecular Characterization of Exploitation of the Polyubiquitination and Farnesylation Machineries of Dictyostelium Discoideum by the AnkB F-Box Effector of Legionella Pneumophila
por: Al-Quadan, Tasneem, et al.
Publicado: (2011)

Cloning and Characterization of Farnesyl Diphosphate Synthase Gene Involved in Triterpenoids Biosynthesis from Poria cocos
por: Wang, Jianrong, et al.
Publicado: (2014)

Dictyostelium discoideum Nucleoside Diphosphate Kinase C Plays a Negative Regulatory Role in Phagocytosis, Macropinocytosis and Exocytosis
por: Annesley, Sarah J., et al.
Publicado: (2011)

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
por: Park, Jaeok, et al.
Publicado: (2017)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
por: Park, Jaeok, et al.
Publicado: (2021)

Biosynthesis of α-Bisabolol by Farnesyl Diphosphate Synthase and α-Bisabolol Synthase and Their Related Transcription Factors in Matricaria recutita L.
por: Tai, Yuling, et al.
Publicado: (2023)

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
por: Pan, Jian-Jung, et al.
Publicado: (2015)

Motility mutants of Dictyostelium discoideum
Publicado: (1982)

Rational design of Lepidoptera-specific insecticidal inhibitors targeting farnesyl diphosphate synthase, a key enzyme of the juvenile hormone biosynthetic pathway
por: Picard, Marie-Ève, et al.
Publicado: (2021)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase
por: Chan, Yueh-Te, et al.
Publicado: (2017)

Lysosomal enzymes in Dictyostelium discoideum are transported to lysosomes at distinctly different rates
Publicado: (1986)

Pathways involved in targeting and secretion of a lysosomal enzyme in Dictyostelium discoideum
Publicado: (1985)

Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum
por: Neelamegan, Dhamodharan, et al.
Publicado: (2012)

Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae
por: Motley, Alison M, et al.
Publicado: (2012)

Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
por: Sucgang, Richard, et al.
Publicado: (2011)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
por: Jin, Tingting, et al.
Publicado: (2022)

Concise synthesis of artemisinin from a farnesyl diphosphate analogue
por: Tang, Xiaoping, et al.
Publicado: (2018)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
por: Ha, Nguyen Thi, et al.
Publicado: (2020)

Dictyostelium Discoideum: A Developmental System
por: Zeldis, Jerome B.
Publicado: (1976)

Selection of chemotaxis mutants of Dictyostelium discoideum
Publicado: (1987)

Spindle and kinetochore morphology of Dictyostelium discoideum
Publicado: (1976)

Prelysosomal acidic vacuoles in Dictyostelium discoideum
Publicado: (1989)

Centromere sequence and dynamics in Dictyostelium discoideum
por: Glöckner, Gernot, et al.
Publicado: (2009)

ABC Transporters in Dictyostelium discoideum Development
por: Miranda, Edward Roshan, et al.
Publicado: (2013)

Retrotransposon Domestication and Control in Dictyostelium discoideum
por: Malicki, Marek, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qf91s1npje8j01jmtod2dtos0v