Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source

Direct phosphorylation of AC2 (adenylyl cyclase 2) by PKC (protein kinase C) affords an opportunity for AC2 to integrate signals from non-canonical pathways to produce the second messenger, cyclic AMP. The present study shows that stimulation of AC2 by pharmacological activation of PKC or muscarinic...

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Detalles Bibliográficos
Autores principales: Shen, Jia X., Wachten, Sebastian, Halls, Michelle L., Everett, Katy L., Cooper, Dermot M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465989/
https://www.ncbi.nlm.nih.gov/pubmed/22906005
http://dx.doi.org/10.1042/BJ20120279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465989/
https://www.ncbi.nlm.nih.gov/pubmed/22906005
http://dx.doi.org/10.1042/BJ20120279

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