Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma

The receptor tyrosine kinase (RTK)/phosphoinositide 3-kinase (PI3K) pathway is fundamental for cancer cell proliferation and is known to be frequently altered and activated in neoplasia, including embryonal tumors. Based on the high frequency of alterations, targeting components of the PI3K signalin...

Descripción completa

Detalles Bibliográficos
Autores principales: Wojtalla, Anna, Salm, Fabiana, Christiansen, Ditte G., Cremona, Tiziana, Cwiek, Paulina, Shalaby, Tarek, Gross, Nicole, Grotzer, Michael A., Arcaro, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466180/
https://www.ncbi.nlm.nih.gov/pubmed/23056595
http://dx.doi.org/10.1371/journal.pone.0047109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466180/
https://www.ncbi.nlm.nih.gov/pubmed/23056595
http://dx.doi.org/10.1371/journal.pone.0047109

Ejemplares similares