Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production

Herein, we describe the synthesis and pharmacological evaluation of novel N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that were designed as novel prototypes of p38 mitogen-activated protein kinase (MAPK) inhibitors. All of the novel synthesized compounds described in this study were evaluated...

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Detalles Bibliográficos
Autores principales: Lacerda, Renata B., da Silva, Leandro L., de Lima, Cleverton K. F., Miguez, Eduardo, Miranda, Ana Luisa P., Laufer, Stefan A., Barreiro, Eliezer J., Fraga, Carlos A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466213/
https://www.ncbi.nlm.nih.gov/pubmed/23056531
http://dx.doi.org/10.1371/journal.pone.0046925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466213/
https://www.ncbi.nlm.nih.gov/pubmed/23056531
http://dx.doi.org/10.1371/journal.pone.0046925

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