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Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

In liver, glucose utilization and lipid synthesis are inextricably intertwined. When glucose availability exceeds its utilization, lipogenesis increases, leading to increased intrahepatic lipid content and lipoprotein secretion. Although the fate of three-carbon metabolites is largely determined by...

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Detalles Bibliográficos
Autores principales: Ido-Kitamura, Yukari, Sasaki, Tsutomu, Kobayashi, Masaki, Kim, Hye-Jin, Lee, Yong-Soo, Kikuchi, Osamu, Yokota-Hashimoto, Hiromi, Iizuka, Katsumi, Accili, Domenico, Kitamura, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466224/
https://www.ncbi.nlm.nih.gov/pubmed/23056614
http://dx.doi.org/10.1371/journal.pone.0047231