Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism

The iminosugar N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice. Thus far the effect of GSL synthesis inhibition on pre-existing...

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Detalles Bibliográficos
Autores principales: Lombardo, Elisa, van Roomen, Cindy P. A. A., van Puijvelde, Gijs H., Ottenhoff, Roelof, van Eijk, Marco, Aten, Jan, Kuiper, Johan, Overkleeft, Herman S., Groen, Albert K., Verhoeven, Arthur J., Aerts, Johannes M. F. G., Bietrix, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466229/
https://www.ncbi.nlm.nih.gov/pubmed/23056165
http://dx.doi.org/10.1371/journal.pone.0038520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466229/
https://www.ncbi.nlm.nih.gov/pubmed/23056165
http://dx.doi.org/10.1371/journal.pone.0038520

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