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Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism
The iminosugar N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice. Thus far the effect of GSL synthesis inhibition on pre-existing...
Autores principales: | Lombardo, Elisa, van Roomen, Cindy P. A. A., van Puijvelde, Gijs H., Ottenhoff, Roelof, van Eijk, Marco, Aten, Jan, Kuiper, Johan, Overkleeft, Herman S., Groen, Albert K., Verhoeven, Arthur J., Aerts, Johannes M. F. G., Bietrix, Florence |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466229/ https://www.ncbi.nlm.nih.gov/pubmed/23056165 http://dx.doi.org/10.1371/journal.pone.0038520 |
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