Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes involved in antioxidant defense through binding to Antioxidant Response Elements (ARE) located in the promoter regions of these genes. To identify Nrf2 activators for the treat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Kai Connie, McDonald, Peter R., Liu, Jie Jerry, Chaguturu, Rathnam, Klaassen, Curtis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466241/
https://www.ncbi.nlm.nih.gov/pubmed/23056183
http://dx.doi.org/10.1371/journal.pone.0044686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466241/
https://www.ncbi.nlm.nih.gov/pubmed/23056183
http://dx.doi.org/10.1371/journal.pone.0044686

Ejemplares similares