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How Metal Substitution Affects the Enzymatic Activity of Catechol-O-Methyltransferase
Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine. The enzymatic activity of COMT is known to be vitally dependent on the nature of the bound meta...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466255/ https://www.ncbi.nlm.nih.gov/pubmed/23056605 http://dx.doi.org/10.1371/journal.pone.0047172 |